Work

P-selectin–deficient mice to study pathophysiology of sickle cell disease

Year: 2020

Type: article

Abstract: Key Points P-selectin–deficient SCD mice are protected from lung vaso-occlusion. P-selectin–deficient SCD mice will be useful in assessing the benefits of anti–P-selectin therapy in diverse complications of SCD.

Source: Blood Advances

DOI: 10.1182/bloodadvances.2019000603

Authors: Margaret F. Bennewitz, Egemen Tutuncuoglu, Shweta Gudapati, Tomasz Brzoska, Simon C. Watkins, Satdarshan P. Monga, Tirthadipa Pradhan-Sundd, Prithu Sundd

Institutions: West Virginia University, University of Pittsburgh

Language: English

Topic: Hemoglobinopathies and Related Disorders

Subfield: Genetics (clinical)

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,800

Funders: National Institutes of Health, National Heart, Lung, and Blood Institute, National Institute of Diabetes and Digestive and Kidney Diseases, National Center for Research Resources

Awards: Request for Zeiss 710 multiphoton 5Live Duoscan Microscope, Request for a Nikon A1R Multiphoton Microscope, Molecular Mechanism of Sickle Cell Hepatic Crisis, Mechanisms of platelet exosome-mediated acute chest syndrome in sickle cell disease, Pulmonary arteriole micro-embolism by platelet-neutrophil aggregates promotes sickle cell disease acute chest syndrome, Pulmonary arteriole occlusion by platelet-neutrophil micro-emboli in Acute Chest Syndrome, Training in Translational Research in Pulmonary Vascular Biology

OpenAlex ID: W3002712267

FWCI: 2.554

Cites: 39

Cited by: 31

Related to: 10