Year: 2020
Type: review
Abstract: The interest in non-coding RNAs, which started more than a decade ago, has still not weakened. A wealth of experimental and clinical studies has suggested the potential of non-coding RNAs, especially the short-sized microRNAs (miRs), to be used as the new generation of therapeutic targets and biomarkers of cardiovascular disease, an ever-growing public health issue in the modern world. Among the hundreds of miRs characterized so far, microRNA-1 (miR-1) and microRNA-21 (miR-21) have received some attention and have been associated with cardiac injury and cardioprotection. In this review article, we summarize the current knowledge of the function of these two miRs in the heart, their association with cardiac injury, and their potential cardioprotective roles and biomarker value. While this field has already been extensively studied, much remains to be done before research findings can be translated into clinical application for patient's benefit.
DOI: 10.3390/ijms21030700
Language: English
Subfield: Cancer Research
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $2,112
Funders: Slovenská Akadémia Vied, Fonds National de la Recherche Luxembourg, Ministerstvo školstva, vedy, výskumu a športu Slovenskej republiky, Ministère de l'Education Nationale, de l'Enseignement Superieur et de la Recherche, Agentúra na Podporu Výskumu a Vývoja, Vedecká Grantová Agentúra MŠVVaŠ SR a SAV
Awards: Štúdium nových mechanizmov kardioprotekcie voči ischemicko-reperfúznemu poškodeniu srdca: úloha extracelulárnych vezikúl, nekódujúcich RNA a vplyv metabolických komorbidít na tieto mechanizmy, G1261355236, G1459474918, Úloha extracelulárnych vezikúl v medziorgánovej komunikácii zahrnutej v kardioprotekcii na diaľku (remote conditioning)., G3201818658, G3544219308, G5323068761, G60520938, OCHRANA SRDCA V SITUÁCIÁCH ZVÝŠENEJ PRODUKCIE VOĽNÝCH KYSLÍKOVÝCH RADIKÁLOV: RADIAČNÉ A REPERFÚZNE POŠKODENIE, G6610369161, G678783632, G6932317159, G7188916646, G791075710
OpenAlex ID: W3002752101