Identification of Psychoplastogenic N , N -Dimethylaminoisotryptamine (isoDMT) Analogues through Structure–Activity Relationship Studies
Year: 2020
Type: article
Abstract: Ketamine, N, N -dimethyltryptamine (DMT), and other psychoplastogens possess enormous potential as neurotherapeutics due to their ability to potently promote neuronal growth. Here, we report the first-ever structure–activity relationship study with the explicit goal of identifying novel psychoplastogens. We have discovered several key features of the psychoplastogenic pharmacophore and used this information to develop N, N -dimethylaminoisotryptamine (isoDMT) psychoplastogens that are easier to synthesize, have improved physicochemical properties, and possess reduced hallucinogenic potential as compared to their DMT counterparts.
Source: Journal of Medicinal Chemistry
Language: English
Subfield: Clinical Psychology
Field: Psychology
Domain: Social Sciences
Open Access status: green
Funders: Paul G. Allen Family Foundation, Genentech Foundation, Hellman Foundation, National Institutes of Health, Genentech, University of California, Davis, National Institute on Alcohol Abuse and Alcoholism, National Institute of Mental Health, National Institute of General Medical Sciences, National Institute of Environmental Health Sciences, National Institute of Child Health and Human Development, Eunice Kennedy Shriver National Institute of Child Health and Human Development
Awards: G1309761578, MIND Institute Intellectual and Developmental Disabilities Research Center, UC Davis Training Program in Chemical Biology, Behavior-based chemical screening for GABAergic and startle modifying drugs, G5144221652, MIND Institute Intellectual and Developmental Disabilities Research Center, Design, Synthesis, and Evaluation of Neural Plasticity-Promoting Analogs of Iboga and Ergoline Alkaloids, UC Davis Environmental Health Sciences Core Center, Learning, Memory, and Plasticity (LaMP) Training Program
OpenAlex ID: W3002940062