Work

Serine phosphorylation of the small phosphoprotein ICAP1 inhibits its nuclear accumulation

Year: 2020

Type: article

Abstract: and in cultured cells and that active PAK4 inhibits ICAP1 nuclear accumulation in a Ser-10-dependent manner. Finally, we show that ICAP1 phosphorylation controls nuclear localization of the ICAP1-KRIT1 complex. We conclude that serine phosphorylation within the ICAP1 N-terminal region can prevent nuclear ICAP1 accumulation, providing a mechanism that regulates KRIT1 localization and signaling, potentially influencing vascular development.

Source: Journal of Biological Chemistry

DOI: 10.1074/jbc.ra119.009794

Authors: Valerie L. Su, Bertrand Simon, Kyle M. Draheim, David A. Calderwood

Institution: Yale University

Language: English

Topic: Protein Kinase Regulation and GTPase Signaling

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: hybrid

Estimated APC paid: $3,430

Funders: American Heart Association, National Heart, Lung, and Blood Institute, National Institute of General Medical Sciences, National Institute of Neurological Disorders and Stroke