Year: 2017
Type: dissertation
Study design: Observational Study
Abstract: Bipolar disorder (BD) is a chronic psychiatric illness and a leading cause of disability worldwide. Several lines of evidence suggest that mitochondrial dysfunction and inflammation are present in BD. Our objective was to investigate if there was evidence for NLRP3 inflammasome activation as a link between inflammation and mitochondrial dysfunction in peripheral samples of BD. Sera, peripheral blood mononuclear cells, and DNA were obtained from 205 participants with type I BD and 205 non-psychiatric controls. We observed large differences between recruitment sites in levels of serum cytokines and L-lactate. However, controls and BD cases were not recruited from the same sites and the observed differences were largely be explained by transit time 協 the time between blood draw and when the sample arrived at the central biospecimens laboratory. The present study highlights problems inherent involving collection of biospecimens for biobanks and provides recommendations for how future studies should be conducted.
Source: TSpace (University of Toronto)
Author: Alexander Pan
Language: English
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W3003503281