Work

Author response: STRIPAK directs PP2A activity toward MAP4K4 to promote oncogenic transformation of human cells

Year: 2020

Type: peer-review

Abstract: ST recruitment of STRIPAK facilitates PP2A-mediated dephosphorylation of MAP4K4 and induces cell transformation highlighting that STRIPAK complex plays a key role in defining PP2A specificity and activity.

Source: eLife

DOI: 10.7554/elife.53003.sa2

Authors: Jong Wook Kim, Christian Berrios, Miju Kim, Amy E Schade, Guillaume Adelmant, Huwate Yeerna, Emily Damato, Amanda Balboni Iniguez, Laurence Florens, Michael P Washburn, Kim Stegmaier, Nathanael S Gray, Pablo Tamayo, Ole Gjoerup, Jarrod A Marto, James DeCaprio, William C Hahn

Institutions: Broad Institute, University of California San Diego, Dana-Farber Cancer Institute, Moores Cancer Center, Harvard University, Brigham and Women's Hospital, Stowers Institute for Medical Research, University of Kansas Medical Center

Language: English

Topic: Protein Kinase Regulation and GTPase Signaling

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: gold

Estimated APC paid: $2,500

OpenAlex ID: W3003610632

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