Year: 2020
Type: dissertation
Study design: Case Report
Abstract: Chronic traumatic encephalopathy (CTE) is a neurodegenerative condition characterized by the perivascular deposition of phosphorylated τ (p-τ) protein aggregates resulting from repetitive mild traumatic brain injury (rTBI).Advances in the ��� have revealed the ������= of repetitive head trauma in the pathogenesis of CTE in contact sports as well as military veterans.In this study we provide evidence of bloodbrain barrier (BBB) disruption in regions of intense perivascular p-τ deposition in a former profession boxer diagnosed with CTE and schizophrenia.P-τ deposition was associated with loss of the tight junction protein claudin-5 and enhanced extravasation of endogenous blood components �������çgen and IgG.We also provide evidence of tight junction disruption in individuals with schizophrenia, with discontinuous claudin-5 immunoreactivity in the parietal cortex.This data highlights a common phenotype of a dysfunctional BBB in individuals with CTE and schizophrenia and may represent a novel correlate of neural dysfunction in individuals at risk of developing CTE and schizophrenia.
Author: Eoin O’Keeffe
Language: English
Subfield: Neurology
Field: Neuroscience
Domain: Life Sciences
Open Access status: green
Funder: Science Foundation Ireland
OpenAlex ID: W3003667594