Work

Quantitative phase imaging of stromal prognostic markers in pancreatic ductal adenocarcinoma

Year: 2020

Type: article

Abstract: New quantitative prognostic markers are needed for improved pancreatic ductal adenocarcinoma (PDAC) prognosis. Second harmonic generation microscopy has been used to show that collagen fiber alignment in PDAC is a negative prognostic factor. In this work, a series of PDAC and normal adjacent tissue (NAT) biopsies were imaged with spatial light interference microscopy (SLIM). Quantitative analysis performed on the biopsy SLIM images show that PDAC fiber structures have lower alignment per unit length, narrower width, and are longer than NAT controls. Importantly, fibrillar collagen in PDAC shows an inverse relationship between survival data and fiber width and length (p < 0.05).

Source: Biomedical Optics Express

DOI: 10.1364/boe.383242

Authors: Michael Fanous, Adib Keikhosravi, Andre Kajdacsy-Balla, Kevin W. Eliceiri, Gabriel Popescu

Institutions: University of Illinois Urbana-Champaign, University of Wisconsin–Madison, University of Illinois Chicago

Language: English

Topic: Digital Holography and Microscopy

Subfield: Atomic and Molecular Physics, and Optics

Field: Physics and Astronomy

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,913