Outcome of children relapsing after first allogeneic haematopoietic stem cell transplantation for acute myeloid leukaemia: a retrospective I‐BFM analysis of 333 children
Year: 2020
Type: article
Study design: Observational Study
Abstract: Outcome of 333 children with acute myeloid leukaemia relapsing after a first allogeneic haematopoietic stem cell transplantation was analyzed. Four-year probability of overall survival (4y-pOS) was 14%. 4y-pOS for 122 children receiving a second haematopoietic stem cell transplantation was 31% and 3% for those that did not (P = <0·0001). Achievement of a subsequent remission impacted survival (P = <0·0001). For patients receiving a second transplant survival with or without achieving a subsequent remission was comparable. Graft source (bone marrow vs. peripheral blood stem cells, P = 0·046) and donor choice (matched family vs. matched unrelated donor, P = 0·029) positively impacted survival after relapse. Disease recurrence and non-relapse mortality at four years reached 45% and 22%.
Source: British Journal of Haematology
DOI: 10.1111/bjh.16441
Authors: Theodor Uden, Alice Bertaina, Jonas Abrahamsson, Marc Ansari, Adriana Balduzzi, Jean‐Pierre Bourquin, Corinne Gerhardt, Marc Bierings, Henrik Hasle, Arjan Lankester, Kirsten Mischke, Andrew S. Moore, Ian Nivison‐Smith, Anna Pieczonka, Christina Peters, Petr Sedlacek, Dirk Reinhardt, Jerry Stein, Birgitta Versluys, Jacek Wachowiak, Leen Willems, Martin Zimmermann, Franco Locatelli, Martin G. Sauer
Institutions: Medizinische Hochschule Hannover, Bambino Gesù Children's Hospital, Sahlgrenska University Hospital, University of Geneva, University Hospital of Geneva, Azienda Ospedaliera San Gerardo, University of Milano-Bicocca, University Children's Hospital Zurich, Princess Máxima Center, Aarhus University Hospital, Leiden University Medical Center, Willem-Alexander Kinderziekenhuis, The University of Queensland, Children's Health Queensland Hospital and Health Service, Poznan University of Medical Sciences, St Anna Children's Hospital, Charles University, University Hospital in Motol, University of Duisburg-Essen, Schneider Children's Medical Center, University Medical Center Utrecht, Ghent University Hospital, Sapienza University of Rome
Language: English
Subfield: Hematology
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W3004179367