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FoxM1 Induces CCl2 Secretion From Hepatocytes Triggering Hepatic Inflammation, Injury, Fibrosis, and Liver Cancer

Year: 2020

Type: article

Abstract: Hepatocellular carcinoma (HCC) is the most frequent primary malignancy of the liver and constitutes the third leading cause of cancer death worldwide.1 Virtually all HCCs arise in patients with chronic liver disease such as chronic viral hepatitis, nonalcoholic fatty liver disease, and alcoholic liver disease. Although etiologic agents such as hepatitis B virus or alcohol are known carcinogens, the reasons for hepatocellular transformation are not fully understood for the majority of chronic liver diseases.

Source: Cellular and Molecular Gastroenterology and Hepatology

DOI: 10.1016/j.jcmgh.2020.01.002

Authors: Aveline Filliol, Robert F. Schwabe

Institutions: Columbia University, Columbia University Irving Medical Center

Language: English

Topic: Liver physiology and pathology

Subfield: Hepatology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,000