Mosquito heat seeking is driven by an ancestral cooling receptor
Year: 2020
Type: article
Abstract: Heat seeking is cool Mosquitoes seek hosts using several cues, one of which is body heat. Greppi et al. hypothesized that cooling-activated receptors could be used for locating mammalian hosts if they were rewired downstream for repulsion responses (see the Perspective by Lazzari). A gene family conserved in insects and known to be responsible for sensing changes in temperature in fruit flies was the starting point. Genome-wide analyses and labeled CRISPR-Cas9 mutants allowed visualization of the receptor in neurons of Anopheles gambiae mosquitoes' antennae and assessment of adult female mosquitoes with a disrupted copy of the receptor. This ancestral insect temperature regulatory system has been repurposed for host-finding by malaria mosquitoes. Science , this issue p. 681 ; see also p. 628
Source: Science
Language: English
Subfield: Cellular and Molecular Neuroscience
Field: Neuroscience
Domain: Life Sciences
Open Access status: green
Funders: National Science Foundation, Howard Hughes Medical Institute, Bill and Melinda Gates Foundation, Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung, National Institutes of Health, National Institute of General Medical Sciences, National Institute of Allergy and Infectious Diseases, National Institute of Neurological Disorders and Stroke
Awards: G1027207465, New roles for chemoreceptor paralogues in Drosophila, G1157793363, Molecular Mechanisms of Thermal Tolerance in Drosophila, G1397777726, G1564704456, G2300543012, G2587410216, Genetic and Biochemical Mechanisms of Regulation, G317489339, Unraveling the polymodal behavior of sensory transduction receptors, G6879419924, G693178540, G7384221059, G797215833, The molecular basis of cold- and hygro-sensing in Drosophila melanogaster and Anopheles gambiae.
OpenAlex ID: W3004459549