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Diffuse T1-MRI White Matter Volume Decrease in Patients with Sickle Cell Disease

Year: 2015

Type: preprint

Abstract: Sickle cell disease (SCD) is a genetic blood disorder associated with anemia, chronic vascular damage, overt stroke, silent cerebral infarctions, and early mortality. Patients with SCD have increased cerebral blood flow to compensate for their anemia but nevertheless exhibit regional cerebralhypo-perfusion and neurocognitive decline. Previous volumetric studies in SCD have shown delayed growth, gray matter (GM) loss, white matter (WM) loss, and decreased cortical thickness compared with control subjects. Diffusion-tensor imaging have demonstrated compromised WM integrity in major fiber pathways diffusely throughout the brain. Further regional investigations of structural outcome could potentially help expand our understanding of the neurobiology of SCD

DOI: 10.13140/rg.2.2.27062.09280

Authors: Soyoung Choi, Bush, Adam, Borzage, Matt, Joshi, Anand, Rajagopalan, Vidya, Coloigner, Julie, Lepore, Natasha, Coates, Thomas D, Wood, John C

Institutions: Children's Hospital Los Angeles, University of Southern California, Laboratoire Traitement du Signal et de l'Image

Language: English

Topic: Hemoglobinopathies and Related Disorders

Subfield: Genetics

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W3004506416

Cites: 10

Cited by: 2

Related to: 10