Year: 2020
Type: review
Abstract: The collection of microbes that live in and on the human body - the human microbiome - can impact on cancer initiation, progression, and response to therapy, including cancer immunotherapy. The mechanisms by which microbiomes impact on cancers can yield new diagnostics and treatments, but much remains unknown. The interactions between microbes, diet, host factors, drugs, and cell-cell interactions within the cancer itself likely involve intricate feedbacks, and no single component can explain all the behavior of the system. Understanding the role of host-associated microbial communities in cancer systems will require a multidisciplinary approach combining microbial ecology, immunology, cancer cell biology, and computational biology - a systems biology approach.
Source: Trends in cancer
Authors: Joao B. Xavier, Vincent B. Young, Joseph Skufca, Fiona Ginty, Traci Testerman, Alexander T. Pearson, Paul Macklin, Amir Mitchell, Ilya Shmulevich, Lei Xie, J. Gregory Caporaso, Keith A. Crandall, Nicole L. Simone, Filipa Godoy-Vitorino, Timothy J. Griffin, Katrine L. Whiteson, Heather H. Gustafson, Daniel J. Slade, Thomas M. Schmidt, Marina R.S. Walther-Antonio, Tal Korem, Bobbie-Jo M. Webb-Robertson, Mark P. Styczynski, W. Evan Johnson, Christian Jobin, Jason M. Ridlon, Andrew Y. Koh, Michael Yu, Libusha Kelly, Jennifer A. Wargo
Institutions: Memorial Sloan Kettering Cancer Center, University of Michigan, Michigan Medicine, Clarkson University, GE Global Research (United States), University of South Carolina, University of Chicago, University of Chicago Medicine Comprehensive Cancer Center, Indiana University Bloomington, Indiana University, University of Massachusetts Chan Medical School, Institute for Systems Biology, Hunter College, Northern Arizona University, Milken Institute, George Washington University, Thomas Jefferson University, Sidney Kimmel Cancer Center, University of Puerto Rico, Medical Sciences Campus, University of Puerto Rico System, University of Minnesota, University of California, Irvine, Seattle Children's Research Institute, Virginia Tech, Mayo Clinic, Columbia University, Pacific Northwest National Laboratory, Georgia Institute of Technology, Boston University, University of Florida, University of Illinois Urbana-Champaign, The University of Texas Southwestern Medical Center, Toyota Technological Institute at Chicago, Albert Einstein College of Medicine, The University of Texas MD Anderson Cancer Center
Language: English
Topic: Gut microbiota and health
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: hybrid
Estimated APC paid: $4,000
OpenAlex ID: W3004519953