Work

The promise of mRNA vaccines: a biotech and industrial perspective

Year: 2020

Type: review

Abstract: mRNA technologies have the potential to transform areas of medicine, including the prophylaxis of infectious diseases. The advantages for vaccines range from the acceleration of immunogen discovery to rapid response and multiple disease target manufacturing. A greater understanding of quality attributes that dictate translation efficiency, as well as a comprehensive appreciation of the importance of mRNA delivery, are influencing a new era of investment in development activities. The application of translational sciences and growing early-phase clinical experience continue to inform candidate vaccine selection. Here we review the state of the art for the prevention of infectious diseases by using mRNA and pertinent topics to the biotechnology and pharmaceutical industries.

Source: npj Vaccines

DOI: 10.1038/s41541-020-0159-8

Authors: Nicholas A. C. Jackson, Kent E. Kester, Danilo Casimiro, Sanjay Gurunathan, Frank DeRosa

Institutions: Coalition for Epidemic Preparedness Innovations, Coalition for Epidemic Preparedness Innovations, Sanofi (United States), Translate Bio (United States)

Language: English

Topic: RNA Interference and Gene Delivery

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,290