Correlation analysis of urine proteins and inflammatory cytokines with osteoporosis in patients with diabetic nephropathy.
Year: 2018
Type: article
Study design: Observational Study
Abstract: OBJECTIVES: To analyze the relationship of urine proteins and inflammatory cytokines with osteoporosis in patients with diabetic nephropathy. METHODS: 76 patients with diabetic nephropathy in Xintai Affiliated Hospital of Taishan Medical University were selected and divided into the combination with osteoporosis group (n=28) and the non-combination with osteoporosis group (n=48). The general data of patients was collected, and T scores of lumbar vertebrae and hips of the patients were recorded. RESULTS: Duration of diabetes mellitus (DM) and levels of glycosylated hemoglobin A1c (HbA1c), fasting plasma glucose (FPG) and fasting insulin (FINS) level, levels of C-reactive protein (CRP), tumor necrosis factor-alpha (TNF-α) and interleukin 6 (IL-6), level of 24h urine protein (24hndb) of patients in the combination with osteoporosis group was significantly higher, while the value of eGFR was lower than that of patients in the non-combination with osteoporosis group. The bone mineral densities (BMDs) and T scores of lumbar vertebrae and hips of patients in the combination with osteoporosis group were statistically significantly lower than those of patients in the non-combination with osteoporosis group. 24hndb, CRP, TNF-α and IL-6 were all negatively correlated with BMD. Duration of DM, FPG, HbA1c, FINS, 24hndb, BMD and inflammatory cytokines had independent predictive values for patients with diabetic nephropathy combined with osteoporosis. CONCLUSION: 24hndb and inflammatory cytokines are closely related to the combination with osteoporosis in patients with diabetic nephropathy.
Source: Europe PMC (PubMed Central)
Author: Zhende Zhao
Institution: Affiliated Hospital of Taishan Medical University
Language: English
Subfield: Nephrology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W3004753490