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Cognitive Correlates of Hippocampal Atrophy and Ventricular Enlargement in Adults with or without Mild Cognitive Impairment

Year: 2019
Type: article
Study design: Observational Study
Abstract: We analyzed structural magnetic resonance imaging data from 58 cognitively normal and 101 mild cognitive impairment subjects. We used a general linear regression model to study the association between cognitive performance with hippocampal atrophy and ventricular enlargement using the radial distance method. Bilateral hippocampal atrophy was associated with baseline and longitudinal memory performance. Left hippocampal atrophy predicted longitudinal decline in visuospatial function. The multidomain ventricular analysis did not reveal any significant predictors.
DOI: 10.1159/000490044
Authors: Naira Goukasian, Shai Porat, Anna Blanken, David Avila, Dimitar Zlatev, Sona Hurtz, Kristy S. Hwang, Jonathan Pierce, Shantanu H. Joshi, Ellen Woo, Liana G. Apostolova
Institutions: University of Vermont, University of Southern California, University of California, Irvine, Massachusetts General Hospital, Drexel University, Emory University, University of California, Los Angeles, Indiana University Indianapolis, Indiana University School of Medicine
Language: English
Field: Medicine
Open Access status: gold
Estimated APC paid: $1,670
OpenAlex ID: W2967938366
FWCI: 3.386
Cites: 67
Cited by: 36
Related to: 10