Work

EXO70D isoforms mediate selective autophagic degradation of type-A ARR proteins to regulate cytokinin sensitivity

Year: 2020

Type: article

Abstract: Significance One of the central regulators of plant growth and development is the phytohormone cytokinin. Likewise, it has become increasingly apparent that autophagy is a critical regulatory process in both plants and animals. Our work provides a mechanistic link between these regulatory processes, demonstrating that autophagy can fine-tune cytokinin perception by modulating the level of the type-A ARRs, which negatively regulate the cellular response to cytokinin. Further, our work sheds light on the mechanism of selective autophagy and on how a particular cargo is targeted for autophagic degradation by a novel autophagy receptor belonging to the EXO70D gene family.

Source: Proceedings of the National Academy of Sciences

DOI: 10.1073/pnas.2013161117

Authors: Atiako Kwame Acheampong, Carly Shanks, Chia-Yi Cheng, G. Eric Schaller, Yasin Dagdas, Joseph J. Kieber

Institutions: University of North Carolina at Chapel Hill, Dartmouth College, Gregor Mendel Institute of Molecular Plant Biology, Austrian Academy of Sciences

Language: English

Topic: Autophagy in Disease and Therapy

Subfield: Cell Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

Funders: National Science Foundation, Directorate for Biological Sciences

Awards: Role of the FEI/ACC pathway in regulating cell wall synthesis, Transcriptional Regulation of the Cytokinin Signaling Network