Risk assessment for hospital admission in patients with COPD; a multi-centre UK prospective observational study
Year: 2020
Type: article
Study design: Observational Study
Abstract: In chronic obstructive pulmonary disease (COPD), acute exacerbation of COPD requiring hospital admission is associated with mortality and healthcare costs. The ERICA study assessed multiple clinical measures in people with COPD, including the short physical performance battery (SPPB), a simple test of physical function with 3 components (gait speed, balance and sit-to-stand). We tested the hypothesis that SPPB score would relate to risk of hospital admissions and length of hospital stay. Data were analysed from 714 of the total 729 participants (434 men and 280 women) with COPD. Data from this prospective observational longitudinal study were obtained from 4 secondary and 1 tertiary centres from England, Scotland, and Wales. The main outcome measures were to estimate the risk of hospitalisation with acute exacerbation of COPD (AECOPD and length of hospital stay derived from hospital episode statistics (HES). In total, 291 of 714 individuals experienced 762 hospitalised AECOPD during five-year follow up. Poorer performance of SPPB was associated with both higher rate (IRR 1.08 per 1 point decrease, 95% CI 1.01 to 1.14) and increased length of stay (IRR 1.18 per 1 point decrease, 95% CI 1.10 to 1.27) for hospitalised AECOPD. For the individual sit-to-stand component of the SPPB, the association was even stronger (IRR 1.14, 95% CI 1.02 to 1.26 for rate and IRR 1.32, 95% CI 1.16 to 1.49 for length of stay for hospitalised AECOPD). The SPPB, and in particular the sit-to-stand component can both evaluate the risk of H-AECOPD and length of hospital stay in COPD. The SPPB can aid in clinical decision making and when prioritising healthcare resources.
Source: PLoS ONE
Institutions: University of Cambridge, British Heart Foundation, University of Nottingham, Nottingham Biomedical Research Centre, GlaxoSmithKline (United States), Centre for Inflammation Research, The Queen's Medical Research Institute, University of Edinburgh, Columbia University Irving Medical Center, Columbia University, Cambridge University Hospitals NHS Foundation Trust, Addenbrooke's Hospital, Cambridge Clinical Trials Unit, National Institute for Health and Care Research, Health Data Research UK, NIHR Cambridge Biomedical Research Centre, Royal Brompton Hospital, GlaxoSmithKline (United Kingdom)
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $1,695
Funders: Wellcome Trust, Scottish Government, National Institute for Health and Care Research, British Heart Foundation, Department of Health and Social Care, University of Cambridge, Public Health Agency, Cambridge University Hospitals, Chief Scientist Office, Scottish Government Health and Social Care Directorate, Medical Research Council, Engineering and Physical Sciences Research Council, Economic and Social Research Council, Innovate UK, Health and Social Care Research and Development Division, NIHR Cambridge Biomedical Research Centre, NIHR Nottingham Biomedical Research Centre, Health Data Research UK
Awards: G1671907826, G1953244154, G2266788633, Large-scale integrative genomic studies of high-dimensional traits in cardiovascular diseases (renewal), G3593139215, G3885225423, G3986547339, G4211044638, G45118444, G5117680084, NIHR Senior Investigator Award, G6787924332, Large-scale integrative studies of risk factors in coronary heart disease: from discovery to application (renewal). (Joint funding with MRC), G762219591, G7939076303, G8254630708, Large-scale integrative studies of risk factors in coronary heart disease: from discovery to application
OpenAlex ID: W3005303779