Work

[Mechanism of ulinastatin in reducing lung inflammatory injury in rats with hemorrhagic shock].

Year: 2019

Type: article

Abstract: OBJECTIVE: To investigate the effect of ulinastatin on the inflammatory mediators and their signaling pathways miR-146a/TLR4/NF-κB in rats with hemorrhagic shock. METHODS: , NF-κB p65, IRAK4, p-IRAK4 (Thr345, Ser346), p-IRAK4 (Thr342) and TRAF6 using Western blotting. The lung histopathology of the rats was examined under optical microscope with HE staining. RESULTS: < 0.01). CONCLUSIONS: Ulinastatin combined with acetated Ringer's solution resuscitation alleviates lung inflammations in rats with hemorrhagic shock possibly by enhancing miR-146a expression to regulate TLR4/NF-κB signaling pathway through a negative feedback mechanism and thus modulate the balance of pro-inflammatory and anti-inflammatory factors.

Source: Europe PMC (PubMed Central)

DOI: 10.12122/j.issn.1673-4254.2019.10.16

Authors: Ying Chen, Zhipeng Xu, Qi Song, Zhenjie Wang, Zhong Ji, Zhaolei Qiu, Feng Cheng, Hai Jiang

Institution: First Affiliated Hospital of Bengbu Medical College

Language: Chinese

Topic: Trauma, Hemostasis, Coagulopathy, Resuscitation

Subfield: Critical Care and Intensive Care Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W3005577847

FWCI: 0.696

Cites: 39

Cited by: 4

Related to: 10