Seasonal Variability and Shared Molecular Signatures of Inactivated Influenza Vaccination in Young and Older Adults
Year: 2020
Type: article
Abstract: The seasonal influenza vaccine is an important public health tool but is only effective in a subset of individuals. The identification of molecular signatures provides a mechanism to understand the drivers of vaccine-induced immunity. Most previously reported molecular signatures of influenza vaccination were derived from a single age group or season, ignoring the effects of immunosenescence or vaccine composition. Thus, it remains unclear how immune signatures of vaccine response change with age across multiple seasons. Here we profile the transcriptional landscape of young and older adults over five consecutive vaccination seasons to identify shared signatures of vaccine response as well as marked seasonal differences. Along with substantial variability in vaccine-induced signatures across seasons, we uncovered a common transcriptional signature 28 days post-vaccination in both young and older adults. However, gene expression patterns associated with vaccine-induced antibody responses were distinct in young and older adults; for example, increased expression of Killer Cell Lectin Like Receptor B1 ( KLRB1 ; CD161 ) 28 days post-vaccination positively and negatively predicted vaccine-induced antibody responses in young and older adults, respectively. These findings contribute new insights for developing more effective influenza vaccines, particularly in older adults.
Source: The Journal of Immunology
Institutions: Yale University, Saint Louis University
Language: English
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Open Access status: green
Funders: National Science Foundation, Yale University, Icahn School of Medicine at Mount Sinai, National Institutes of Health, National Institute on Aging, National Heart, Lung, and Blood Institute, National Institute of Allergy and Infectious Diseases, National Institute of Biomedical Imaging and Bioengineering, National Center for Research Resources, National Center for Advancing Translational Sciences
Awards: Convergent Graduate Training in Engineering, Physics and Biology, Yale Biomedical Supercomputer, Host-Pneumococcal Interaction in the Lung, G292646880, Midcareer Award in Translational Immunology of Aging, NLRP3 Inflammasome Activation and Mitochondrial Function in the setting of Aging and HIV Infection, G4541402840, High Performance Computing Instrumentation for Yale University Biomedical HPC Cen, Graduate Research Fellowship Program, The effects of age and HIV infection on C-type lectin receptor function, G9000075367, G9000257349, Immune signatures of vaccine responses in vulnerable populations, Yale Clinical and Translational Science Award, Training in Investigative Infectious Diseases, Claude D. Pepper Older Americans Independence Center at Yale
OpenAlex ID: W3005586026