Radiotracer Development for Bacterial Imaging
Year: 2020
Type: review
Abstract: Bacterial infections remain a major threat to humanity and are a leading cause of death and disability. Antimicrobial resistance has been declared as one of the top ten threats to human health by the World Health Organization, and new technologies are urgently needed for the early diagnosis and monitoring of deep-seated and complicated infections in hospitalized patients. This review summarizes the radiotracers as applied to imaging of bacterial infections. We summarize the recent progress in the development of pathogen-specific imaging and the application of radiotracers in understanding drug pharmacokinetics as well as the local biology at the infection sites. We also highlight the opportunities for medicinal chemists in radiotracer development for bacterial infections, with an emphasis on target selection and radiosynthetic approaches. Imaging of infections is an emerging field. Beyond clinical applications, these technologies could provide unique insights into disease pathogenesis and expedite bench-to-bedside translation of new therapeutics.
Source: Journal of Medicinal Chemistry
Language: English
Subfield: Radiology, Nuclear Medicine and Imaging
Field: Medicine
Domain: Health Sciences
Open Access status: green
Awards: Development of 11C-PABA as a bacteria-specific imaging agent for spinal infections, Novel Imaging Tracers for Rapid and Noninvasive Assessment of Bacterial Infection, G2677061707, Molecular Imaging for Pulmonary Infections and Inflammation, Preclinical modeling to study Tuberculous Meningitis, G5933336340, Next generation molecular imaging and therapy with radionuclides
OpenAlex ID: W3005684149