Work

Development and Characterization of an Anisotropic Biomimetic Polymeric Patch to Improve the Durability of Surgical Heart Valve Repair

Year: 2020

Type: article

Abstract: Objective: Patches currently used for valve repair have suboptimal mechanical and biocompatibility performance. We hypothesize that a biostable “biomimetic” patch that replicates the three-layer architecture and the anisotropic mechanical properties of a native leaflet will display better durability. Our objective is to fabricate this biomimetic patch, test it mechanically and biologically and compare it to commercial patches and native leaflets.

Source: Structural Heart

DOI: 10.1080/24748706.2020.1717209

Authors: Mingze Sun, Caroline Giuglaris, Richard Li, Giovanni Ferrari, Emile Bacha, Jeffrey Kysar, David Kalfa

Institutions: Morgan Stanley Children's Hospital, Columbia University Irving Medical Center, Columbia University

Language: English

Topic: Cardiac Valve Diseases and Treatments

Subfield: Cardiology and Cardiovascular Medicine

Field: Medicine

Domain: Health Sciences

Open Access status: hybrid

Estimated APC paid: $2,340

OpenAlex ID: W3005697935

FWCI: 0.309

Cites:

Cited by: 3

Related to: 10