High mobility group protein B1 (HMGB1) interacts with receptor for advanced glycation end products (RAGE) to promote airway smooth muscle cell proliferation through ERK and NF-κB pathways.
Year: 2019
Type: article
Abstract: BACKGROUND: High-mobility graoup box protein 1 (HMGB1) has been shown to mediate a wide range of pathologic responses by interacting with RAGE (receptor for advanced glycation endproducts) and TLRs (Toll-like receptors). Our previous study showed that HMGB1 has been involved in pathogenesis of airway remodeling in an allergen-induced chronic mice asthma model. Increased airway smooth muscle (ASM) mass is a vital feature of airway remodeling. OBJECTIVE: To evaluate the effect of HMGB1 on proliferation of ASMs and the underlying mechanisms. METHODS: B signaling pathways. RESULTS: B. CONCLUSION: B signaling pathways.
Source: PubMed
Authors: Dongming Qu, Zhougui Ling, Xiaoyu Tan, Yan Chen, Qinghua Huang, Mengze Li, Tangjuan Liu, Changchun Hou, Yiqiang Chen
Language: English
Subfield: Clinical Biochemistry
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W3005880698