Work

Staphylococcus aureus Fibronectin Binding Protein A Mediates Biofilm Development and Infection

Year: 2020

Type: article

Abstract: Implanted medical device-associated infections pose significant health risks, as they are often the result of bacterial biofilm formation. Staphylococcus aureus is a leading cause of biofilm-associated infections which persist due to mechanisms of device surface adhesion, biofilm accumulation, and reprogramming of host innate immune responses. We found that the S. aureus fibronectin binding protein A (FnBPA) is required for normal biofilm development in mammalian serum and that the SaeRS two-component system is required for functional FnBPA activity in serum.

Source: Infection and Immunity

DOI: 10.1128/iai.00859-19

Authors: Casey M. Gries, Trevor Biddle, Jeffrey L. Bose, Tammy Kielian, David D. Lo

Institutions: University of California, Riverside, University of Kansas Medical Center, University of Nebraska Medical Center

Language: English

Topic: Antimicrobial Resistance in Staphylococcus

Subfield: Infectious Diseases

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institutes of Health, National Institute of Allergy and Infectious Diseases