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High glucose triggers multiple cellular stress signaling in pancreatic β-cells and potentiate proinflammation and β-cell dysfunction

Year: 2020

Type: article

Abstract: Pancreatic β-cells are highly susceptible to high glucose-induced metabolic stress and β-cell dysfunction is emerging as an early event in the etiology of type 2 diabetes. The current study investigated the effects of high glucose-induced multiple cellular stress signaling that could promote proinflammation and β-cell dysfunction. The study also tested the effect of metformin, lactoferrin and tauroursodeoxycholic acid (TUDCA, an inhibitor of ER stress) in providing protection for β-cells.

Source: Indian Journal of Inflammation Research

DOI: 10.15305/ijir/v4i1/327

Authors: Srividhya Raghavan, Viswanathan Mohan, Muthuswamy Balasubramanyam

Language: English

Topic: Pancreatic function and diabetes

Subfield: Surgery

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W3005884462

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