Work

Modified Sialic Acids on Mucus and Erythrocytes Inhibit Influenza A Virus Hemagglutinin and Neuraminidase Functions

Year: 2020

Type: article

Abstract: Sialic acids (Sia) are involved in numerous different cellular functions and are receptors for many pathogens. Sia come in chemically modified forms, but we lack a clear understanding of how they alter interactions with microbes. Here, we examine the expression of modified Sia in mouse tissues, on secreted mucus in saliva, and on erythrocytes, including those from IAV host species and animals used in IAV research. These Sia forms varied considerably among different animals, and their inhibitory effects on IAV NA and HA activities and on bacterial sialidases (neuraminidases) suggest a host-variable protective role in secreted mucus.

Source: Journal of Virology

DOI: 10.1128/jvi.01567-19

Authors: Karen N. Barnard, Brynn K. Alford-Lawrence, David W. Buchholz, Brian R. Wasik, Justin R. LaClair, Hai Yu, Rebekah Honce, Stefan Ruhl, Petar Pajic, Erin K. Daugherity, Xi Chen, Stacey L. Schultz-Cherry, Hector C. Aguilar, Ajit Varki, Colin R. Parrish

Institutions: Cornell University, New York State College of Veterinary Medicine, University of California, Davis, St. Jude Children's Research Hospital, University of Tennessee Health Science Center, University at Buffalo, State University of New York, University of California San Diego

Language: English

Topic: Glycosylation and Glycoproteins Research

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institutes of Health, National Cancer Institute, National Institute of General Medical Sciences, National Institute of Allergy and Infectious Diseases, National Institute of Dental and Craniofacial Research, Common Fund

Awards: G103575219, The Evolutionary and Biological Bases of Host Switching in Viruses, Microbial Recognition of Sialic Acid Diversity in the Oral Cavity, Mechanisms of Nipah virus fusion and entry, Effects of Commons Sialic Acid Modifications on Virus Binding and Infection, Exploring the biology ofÃÂ O-acetylÃÂ sialic acids using stable syntheticÃÂ mimics, HARNESSING THE ORAL MICROBIOME TO CREATE NOVEL GLYCAN-BINDING PROBES, G7059131728, Sialoglycan-Recognizing Probes for Defining Sialoglycomes in Biological Systems

OpenAlex ID: W3005940631

FWCI: 2.593

Cites: 96

Cited by: 60

Related to: 10