Year: 2019
Type: dissertation
Abstract: Autophagy is a highly conserved eukaryotic homeostasis process that facilitates degradation of intracellular components.During times of starvation, autophagy is vital in replenishing pools of biosynthetic precursors through degradation of these cytosolic components, and it also plays key roles in responding to cytotoxic stress as it acts to specifically degrade damaged organelles, aggregated proteins, and pathogens.This is achieved by the formation of an autophagosome, a double membrane organelle that engulfs cytoplasmic components and then fuses with the vacuole or the lysosome leading to degradation of the engulfed components.Of note, defects in autophagy have been genetically linked with cancer, neurodegeneration, inflammation and aging, highlighting the importance of deeply understanding this process.
Authors: Ramirez Montero, Daniel Fernando.
Language: English
Subfield: Cell Biology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W3006109197