Work

Shikonin induces apoptosis and necroptosis in pancreatic cancer via regulating the expression of RIP1/RIP3 and synergizes the activity of gemcitabine.

Year: 2017

Type: article

Abstract: . Moreover, SK induced apoptosis and necroptosis in different pancreatic cancer cells by regulating RIP1 and RIP3 expression. The expression of RIP3 correlated with their necrotic response. These results suggest that the combination of SK and gemcitabine may be a promising chemotherapy regimen for pancreatic cancer.

Source: PubMed

Authors: Congying Chen, Wenqin Xiao, Li Huang, Ge Yu, Jianbo Ni, Lijuan Yang, Rong Wan, Guoyong Hu

Institutions: Shanghai Jiao Tong University, Shanghai First People's Hospital, Tongji University, Shanghai Tenth People's Hospital

Language: English

Topic: Cell death mechanisms and regulation

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W3006122381

FWCI: 2.046

Cites: 28

Cited by: 57

Related to: 10