Work

Selective Binding of Dopamine and Epinephrine in Water by Molecularly Imprinted Fluorescent Receptors

Year: 2020

Type: article

Abstract: Catecholamines play important roles in biology but their structural similarity makes it challenging to construct synthetic receptors with selective binding. A combination of covalent and noncovalent binding groups in the hydrophobic core of water‐soluble nanoparticles enabled them to recognize dopamine and epinephrine with an association constant ( K a ) of 3–4×10 4 M −1 in water, an order of magnitude higher than those of previously reported synthetic hosts. In addition, minute structural changes among analogues were detected including the addition or removal of a single hydroxyl or methyl group.

Source: Chemistry - An Asian Journal

DOI: 10.1002/asia.201901783

Authors: Likun Duan, Yan Zhao

Institution: Iowa State University

Language: English

Topic: Supramolecular Chemistry and Complexes

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: green

Funder: National Institute of General Medical Sciences

Award: G4564608278