Targeting Age-Related Pathways in Heart Failure
Year: 2020
Type: review
Abstract: During aging, deterioration in cardiac structure and function leads to increased susceptibility to heart failure. The need for interventions to combat this age-related cardiac decline is becoming increasingly urgent as the elderly population continues to grow. Our understanding of cardiac aging, and aging in general, is limited. However, recent studies of age-related decline and its prevention through interventions like exercise have revealed novel pathological and cardioprotective pathways. In this review, we summarize recent findings concerning the molecular mechanisms of age-related heart failure and highlight exercise as a valuable experimental platform for the discovery of much-needed novel therapeutic targets in this chronic disease.
Source: Circulation Research
Authors: Haobo Li, Margaret H. Hastings, James Rhee, Lena E. Trager, Jason D. Roh, Anthony Rosenzweig
Institutions: Harvard University, Massachusetts General Hospital
Language: English
Subfield: Cardiology and Cardiovascular Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: green
Awards: Activin type II receptor activity in age-related frailty and heart failure, Does Exercise Induce Cardiomyogenesis?, Role of Activin Type II receptor signaling in age-related heart failure, Discovery and characterization of lncRNAs involved in cardiac exercise phenotypes, The Role of Family with Sequence Similarity 3D (FAM3D) in Cardioprotection and Inflammation after Myocardial Infarction, Understanding the Cardiac Benefits of Exercise at the Cellular and Molecular Level, Role of miR-222 in pathological hypertrophy and heart failure
OpenAlex ID: W3006673240