Application and Pitfalls of Immunohistochemistry in Diagnosis of Challenging Genitourinary Cases
Year: 2020
Type: review
Abstract: CONTEXT.—: Immunohistochemistry (IHC) has become increasingly important in the evaluation of pathologic conditions in the genitourinary (GU) organs. In addition to careful evaluation of hematoxylin-eosin sections and generation of a differential diagnosis, choosing the optimal panel of IHC markers becomes even more important when the biopsy material is very limited. The following summary of our experience supplemented with relevant literature review exemplifies how to use IHC to facilitate pathologic diagnosis in the GU system. OBJECTIVE.—: To describe our experience with the most common immunohistochemical markers used in GU pathology. DATA SOURCES.—: Institutional experience and literature search comprise our data sources. CONCLUSIONS.—: Application of IHC provides enormous benefits to the interpretation of GU pathologic conditions, including benign and malignant lesions. However, both insufficient and excessive types of use of IHC, as well as incorrect interpretations in common and rare GU conditions, could present pitfalls in diagnosis.
Authors: Jenny Ross, Guangyuan Li, Ximing J. Yang
Institution: Northwestern University
Language: English
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W3006989789