Mouse tail models of secondary lymphedema: fibrosis gradually worsens and is irreversible.
Year: 2020
Type: article
Abstract: T cell infiltration, tail swelling, and subcutaneous adipose hyperplasia were alleviated over time. We also show that necrosis could be effectively avoided by paying attention to several details in the modeling process. As animal models play a key role in exploring the pathophysiology of disease, our findings provide strong support for the study of lymphedema. The irreversibility of fibrosis suggests the importance of treating lymphedema by preventing fibrosis development.
Source: Europe PMC (PubMed Central)
Authors: Chenxiao Zhou, Wanchun Su, Haotian Han, Na Li, Gang Ma, Lei Cui
Institutions: Capital Medical University, Beijing Shijitan Hospital
Language: English
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W3007330546