Year: 1989
Type: dissertation
Abstract: Anaesthesia may alter acutely the disposition of drugs in the body. This may be produced by changes in hepatic blood flow, by changes in hepatic drug-metabolising enzyme activity or by changes in the distribution of the drug in the body. The known effect of anaesthesia on these determinants is described. The control of and factors affecting hepatic blood flow are discussed, as are the methods of measuring it. Hepatic drug metabolising enzymes are described. Their activity, mathematical models,methods of assessment and factors altering activity are discussed.
Author: Charles S. Reilly
Language: English
Subfield: Pharmacology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W3007526960