Work

USP7 stabilizes EZH2 and enhances cancer malignant progression.

Year: 2020

Type: article

Abstract: in mouse models. Overexpression of USP7 promoted the expression of EZH2 protein, but overexpression of a USP7 mutant did not change the EZH2 level. Consistently, knockdown of USP7 resulted in a striking decrease in EZH2 protein levels in human cancer cells. Functionally, USP7 overexpression promoted cell growth and invasion via deubiquitination of EZH2. Consistently, downregulation of USP7 inhibited cell migration and invasion in cancer. More importantly, knockdown of USP7 inhibited tumor growth, while USP7 overexpression exhibited opposed effect in mice. Our results indicate that USP7 regulates EZH2 via its deubiquitination and stabilization. The USP7/EZH2 axis could present a new promising therapeutic target for cancer patients.

Source: PubMed Central

Authors: Nana Zheng, Man Chu, Min Lin, Youhua He, Zhiwei Wang

Institutions: Beth Israel Deaconess Medical Center, Harvard University, Wenzhou Medical University

Language: English

Topic: Ubiquitin and proteasome pathways

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W3007544003

FWCI: 1.091

Cites: 52

Cited by: 20

Related to: 10