MicroRNA-23b attenuates the H2O2-induced injury of microglial cells via TAB3/NF-κB signaling pathway.
Year: 2018
Type: article
Abstract: . Moreover, our data showed TAB3, an upstream positive regulator of the NF-κB pathway, was proven to be a target of miR-23b in BV-2 cells. Most importantly, we demonstrated that overexpression of miR-23b attenuated the apoptosis by inhibiting the expression of TAB3. These findings suggested that miR-23b protected BV-2 cells from apoptosis by modulating the NF-κB pathway and could serve as a new strategy for the treatment of SCI.
Source: Europe PMC (PubMed Central)
Authors: Xin Zhou, Jiajun Chen, Hongjun Zhang, Xiao Chen, Gaohai Shao
Language: English
Subfield: Cancer Research
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W3007627336