Work

Template-guided selection of RNA ligands using imine-based dynamic combinatorial chemistry

Year: 2020

Type: article

Abstract: This study establishes the applicability of imine-based dynamic combinatorial chemistry to discover non-covalent ligands for RNA targets. We elucidate properties underlying the reactivity of arylamines and demonstrate target-guided amplification of tight binders in an amiloride-based dynamic library.

Source: Chemical Communications

DOI: 10.1039/d0cc00266f

Authors: Aline Umuhire Juru, Zhengguo Cai, Adina Jan, Amanda E. Hargrove

Institution: Duke University

Language: English

Topic: Supramolecular Chemistry and Complexes

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: green

Funders: Prostate Cancer Foundation, Duke University, National Institute of Allergy and Infectious Diseases, Division of Chemistry

Awards: G2256451571, The Center for HIV RNA Studies (CRNA)