Work

SIX4 promotes metastasis through STAT3 activation in breast cancer.

Year: 2020

Type: article

Abstract: . Mechanistically, SIX4 directly interacted with STAT3 and promoted the phosphorylated STAT3 nuclear translocation, thereby inducing EMT program activation. Collectively, our findings demonstrated that SIX4 may be a promising target for intervention to prevent cancer metastasis.

Source: PubMed

Authors: Xuling Sun, Jin Ma, Qianzhi Chen, Zhenlin Hou, Xuelai Luo, Guihua Wang, Jing Wang, Junbo Hu, Zhixin Cao

Institutions: Shihezi University, First Affiliated Hospital of Shihezi University Medical College, Tongji Hospital, Huazhong University of Science and Technology, People's Hospital of Xinjiang Uygur Autonomous Region

Language: English

Topic: Cytokine Signaling Pathways and Interactions

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W3007903937

FWCI: 1.797

Cites: 21

Cited by: 27

Related to: 10