Work

miR-193a-5p promotes pancreatic cancer cell metastasis through SRSF6-mediated alternative splicing of OGDHL and ECM1.

Year: 2020

Type: article

Abstract: . The mechanistic investigation suggested that miR-193a-5p modulated oxoglutarate dehydrogenase-like (OGDHL) and extracellular matrix protein 1 (ECM1) AS by targeting serine/arginine-rich splicing factor 6 (SRSF6), leading to the activation of the epithelial-to-mesenchymal transition (EMT) process. Together, our findings highlighted the role of miR-193a-5p-targeting SRSF6 in pancreatic cancer metastasis, which may serve as a novel target for pancreatic cancer diagnosis and therapy.

Source: PubMed

Authors: Manman Li, Pandi Wu, Zhaocong Yang, Siwei Deng, Lingyu Ni, Yanfeng Zhang, Liang Jin, Yi Pan

Institutions: China Pharmaceutical University, State Key Laboratory of Natural Medicine, Nanjing Children's Hospital, Second Affiliated Hospital of Nanjing Medical University

Language: English

Topic: MicroRNA in disease regulation

Subfield: Cancer Research

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W3008179935

FWCI: 3.482

Cites: 57

Cited by: 57

Related to: 10