Achyranthes bidentata extract protects chondrocytes functions through suppressing glycolysis and apoptosis via MAPK/AKT signaling axis.

Year: 2020

Type: article

Abstract: . Mechanically, ABE activated MAPK signaling pathway and suppressed AKT signaling pathway, therefore, reducing the glycolysis to provide survival benefits. We extended our analysis by verifying insulin-like growth factor 1 (IGF-1) and MAP kinase 1 (MEK1) in chondrocytes function. Depletion of either IGF-1 or MEK1 impaired AKT expression and phosphorylation, leading to the enhanced chondrocyte apoptosis and reduced cell proliferation. In conclusion, our study provided systematic view and molecular basis for ABE to serve as potential intervention of OA via suppressing AKT signaling.

Source: PubMed Central

Authors: Dujun Ma, Yuan Li, Wei Xiao, Liping Peng, Lixin Wang, Zhouwei Liao, Liekui Hu

Institutions: Shenzhen Traditional Chinese Medicine Hospital, Shenzhen Second People's Hospital, Guangzhou University of Chinese Medicine

Language: English

Topic: Osteoarthritis Treatment and Mechanisms

Subfield: Rheumatology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W3008429291

FWCI: 1.93

Cites: 42

Cited by: 19

Related to: 10