Work

Downregulated expression of hsa_circ_0037515 and hsa_circ_0037516 as novel biomarkers for non-small cell lung cancer.

Year: 2020

Type: article

Abstract: mRNA, hsa_circ_0037515, and hsa_circ_0037516 are significantly downregulated in 61 paired samples of NSCLC compared to adjacent lung tissues (P < 0.01), and that the areas under the ROC curves for the two circRNAs (0.81 and 0.82, respectively) are indicative of diagnostic value. Furthermore, the significance was improved by considering the two circRNAs in combination (area under the ROC curve, 0.90). Our results suggest that hsa_circ_0037515 and hsa_circ_0037516 serve as novel potential biomarkers for the diagnosis of NSCLC.

Source: PubMed

Authors: Dunmei Zhao, Honggang Liu, Huachao Liu, Xueqing Zhang, Meng Zhang, Vijay Kumar Kolluri, Xulong Feng, Zhenglei He, Minghua Wang, Ting'an Zhu, Xiaolong Yan, Yinghui Zhou

Institutions: Soochow University, Tang Du Hospital, Air Force Medical University, University of Rochester

Language: English

Topic: Circular RNAs in diseases

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W3008596991

FWCI: 1.072

Cites: 26

Cited by: 21

Related to: 10