Work

Epinephrine increases malignancy of breast cancer through p38 MAPK signaling pathway in depressive disorders.

Year: 2019

Type: article

Abstract: OBJECTIVE: To uncover the possible mechanism and the effects of epinephrine on tumor growth in depression. MATERIALS AND METHODS: . RESULTS: . These two effects were significantly attenuated by propranolol (a β-adrenergic receptor antagonist). CONCLUSIONS: These findings suggest that activation of epinephrine-induced p38 MAPK signaling pathway enhances the malignancy of breast cancer in depressive disorders. More effective psychological intervention might improve prognosis of cancer patients.

Source: Europe PMC (PubMed Central)

Authors: Xueyan Ouyang, Zhen Zhu, Chao Yang, Li Wang, Gang Ding, Feng Jiang

Institutions: Shanghai Jiao Tong University, XinHua Hospital, Shanghai University, Shanghai International Medical Center, Xinhua Translational Institute for Cancer Pain

Language: English

Topic: Cancer, Stress, Anesthesia, and Immune Response

Subfield: Cancer Research

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W3008636818

FWCI: 0.749

Cites: 29

Cited by: 23

Related to: 10