Work

Proanthocyanidins in grape seeds: An updated review of their health benefits and potential uses in the food industry

Year: 2020

Type: article

Abstract: Grape seeds are rich sources of proanthocyanidins, which comprise polyhydroxyflavan oligomers or polymers. The beneficial health properties of grape seed proanthocyanidins are attributed to their conjugated and colonic metabolites. There is potential for a two-way relationship between the gut microbiota and grape seed proanthocyanidin. In particular, numerous in vitro and in vivo studies have demonstrated that grape seed proanthocyanidins appear to exert pharmacological effects. These include anti-oxidant, anti-microbial, anti-obesity, anti-diabetic, anti-neurodegenerative, anti-osteoarthritis, anti-cancer, and cardio- and eye-protective properties. In this review, it is aimed to summarize the current literature regarding grape seed proanthocyanidins, focusing on the recently proposed mechanisms of action from clinical trials considered to underlie pharmacological and disease-preventing properties, along with their bioavailability, toxicology, and safety with regard to potential utilization in the food industry.

Source: Journal of Functional Foods

DOI: 10.1016/j.jff.2020.103861

Author: Nurhan Unusan

Institution: KTO Karatay University

Language: English

Topic: Phytochemicals and Antioxidant Activities

Subfield: Biochemistry (medical)

Field: Medicine

Domain: Health Sciences

SDGs: Good health and well-being, Zero hunger

Open Access status: gold

Estimated APC paid: $2,960