Work

SPOCD1 promotes the proliferation and metastasis of glioma cells by up-regulating PTX3.

Year: 2018

Type: article

Abstract: assays showed that knockdown of SPOCD1 significantly inhibited cell proliferation and colony formation capacities in U373 and U87 cells. In a xenograft model of glioma, SPOCD1 was also found to inhibit tumor growth. In addition, knockdown of SPOCD1 was shown to inhibit cell migration and invasion in glioma U373 and U87 cells. SPOCD1 positively regulated the expression of Pentraxin 3 (PTX3), whereas overexpression of PTX3 attenuated SPOCD1 knockdown-mediated inhibition of cell proliferation, migration and invasion in glioma cells. Our observations suggest that SPOCD1 promotes the proliferation and metastasis of glioma cells through regulating PTX3. Our data might provide novel evidence for the diagnosis and treatment of glioma in clinic.

Source: PubMed

Authors: Quan Liu, Xiao-Yu Wang, Yuan-Yuan Qin, Xian-Lei Yan, Hong-Mou Chen, Qi-Dan Huang, Jia-Kang Chen, Jie-Min Zheng

Institutions: Guangxi Medical University, Fourth Affiliated Hospital of Guangxi Medical University, Guangzhou University of Chinese Medicine

Language: English

Topic: Glioma Diagnosis and Treatment

Subfield: Genetics

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W3008761832

FWCI: 1.231

Cites: 21

Cited by: 49

Related to: 10