Year: 2019
Type: conference-paper
Study design: Clinical Trial
Abstract: This research evaluated whether topical anesthetic efficacy increases on palatal mucosa pretreated with microneedles. In this crossover, randomized, double-blind study, 20 male volunteers were submitted to topical application of microneedles or flat patches on palatal mucosa, bilaterally in the canine region followed by topical anesthesia procedure with EMLA® (Eutectic mixture of lidocaine and prilocaine) during 2 or 5 minutes. Immediately after, an infiltrative anesthesia was performed by using a 30-gauge short needle and 0.3 mL of lidocaine 2% with epinephrine 1:100,000. Pain sensation during needle insertion and local anesthetic injection was evaluated by using 2 different visual analogical scale (VAS). VAS (in mm) results were submitted to the Mann-Whitney test (? = 5%). The use of microneedle as a pretreatment of palatal mucosa did not increase topical anesthetic efficacy of EMLA in reducing pain during needle insertion or local anesthetic injection after 2 min of topical application. However the efficacy of EMLA after 5 minutes of application resulted in reduction of pain during needle insertion, but not to local anesthetic injection (p>0.05). In conclusion, microneedle treatment of palatal mucosa was able to increase topical anesthetic efficacy of EMLA®.
Source: Resumos do...
Authors: Gabriela Augusto, Michelle Leite, Stephany Santos, Nádia Moreira, Henrique Abdalla, Maria Volpato, Harvinder Gill, Francisco Groppo
Language: English
Subfield: Oral Surgery
Field: Dentistry
Domain: Health Sciences
Open Access status: hybrid
OpenAlex ID: W3008765976