Year: 2020
Type: review
Abstract: The tightly structured neural retina has a unique vascular network comprised of three interconnected plexuses in the inner retina (and choroid for outer retina), which provide oxygen and nutrients to neurons to maintain normal function. Clinical and experimental evidence suggests that neuronal metabolic needs control both normal retinal vascular development and pathological aberrant vascular growth. Particularly, photoreceptors, with the highest density of mitochondria in the body, regulate retinal vascular development by modulating angiogenic and inflammatory factors. Photoreceptor metabolic dysfunction, oxidative stress, and inflammation may cause adaptive but ultimately pathological retinal vascular responses, leading to blindness. Here we focus on the factors involved in neurovascular interactions, which are potential therapeutic targets to decrease energy demand and/or to increase energy production for neovascular retinal disorders.
DOI: 10.3390/ijms21041503
Language: English
Subfield: Ophthalmology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,112
Funders: U.S. Department of Veterans Affairs, BrightFocus Foundation, Boston Children's Hospital, Little Giraffe Foundation, Ögonfonden, Deutsche Forschungsgemeinschaft, Vetenskapsrådet, Manpei Suzuki Diabetes Foundation, De Blindas Vänner, National Institutes of Health, Intellectual and Developmental Disabilities Research Center, Manton Center for Orphan Disease Research, Boston Children's Hospital, National Heart, Lung, and Blood Institute, National Eye Institute, National Institute of Diabetes and Digestive and Kidney Diseases
Awards: G1717713335, G1753580265, Inflammatory Resolution and Vascular Restoration in Diabetic Retinopathy, Molecular Defence Against Retinopathy of Prematurity: Diagnosis, Prevention, and Treatment, G3530891529, The Mechanism of Immune-Vascular Crosstalk in Retinopathy, Photoreceptor Determination of Retinal Blood Vessel Growth in Retinopathy, G3916677169, G4765866428, G5808301577, G5945485887, G6112328604, G6375076433, G6620266270, G7246432524, Mechanisms of Retinal Vascular Permeability in Diabetes, G8884401024, Michigan Diabetes Research Center (MDRC), Unraveling the role of tPA in the neurovascular unit
OpenAlex ID: W3008851651