Data from a terminated study on iron oxide nanoparticle magnetic resonance imaging for head and neck tumors

Year: 2020

Type: data-paper

Abstract: Node positive head and neck squamous cell carcinomas (HNSCCs) patients exhibit worse outcomes in terms of regional neck control, risk for distant metastases and overall survival. Smaller non-palpable lymph nodes may be inflammatory or may harbor clinically occult metastases, a characterization that can be challenging to make using routine imaging modalities. Ferumoxytol has been previously investigated as an intra-tumoral contrast agent for magnetic resonance imaging (MRI) for intracranial malignancies and lymph node agent in prostate cancer. Hence, our group was motivated to carry out a prospective feasibility study to assess the feasibility of ferumoxytol dynamic contrast enhanced (DCE)-weighted MRI relative to that of gadolinium-based DCE-MRI for nodal and primary tumor imaging in patients with biopsy-proven node-positive HNSCC or melanoma. Although this institutional review board (IRB)-approved study was prematurely terminated because of an FDA black box warning, the investigators sought to curate and publish this unique dataset of matched clinical, and anatomical and DCE MRI data for the enrolled five patients to be available for scientists interested in molecular imaging.

Source: Scientific Data

DOI: 10.1038/s41597-020-0392-z

Authors: Hesham Elhalawani, Musaddiq J. Awan, Yao Ding, Abdallah S. R. Mohamed, Ahmed K. Elsayes, Ibrahim Abu-Gheida, Jihong Wang, John Hazle, G. Brandon Gunn, Stephen Y. Lai, Steven J. Frank, Lawrence E. Ginsberg, David I. Rosenthal, Clifton D. Fuller

Institutions: The University of Texas MD Anderson Cancer Center, Medical College of Wisconsin, The University of Texas Health Science Center at Houston

Language: English

Topic: MRI in cancer diagnosis

Subfield: Radiology, Nuclear Medicine and Imaging

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,870

Funders: National Science Foundation, Elekta, Andrew Sabin Family Foundation, National Institutes of Health, University of Texas MD Anderson Cancer Center, National Cancer Institute, National Institute of Biomedical Imaging and Bioengineering, National Institute of Dental and Craniofacial Research

OpenAlex ID: W3008910477