A new role for histone demethylases in the maintenance of plant genome integrity
Year: 2020
Type: article
Abstract: Histone modifications deposited by the Polycomb repressive complex 2 (PRC2) play a critical role in the control of growth, development and adaptation to environmental fluctuations in most multicellular eukaryotes. The catalytic activity of PRC2 is counteracted by Jumonji-type (JMJ) histone demethylases, which shapes the genomic distribution of H3K27me3. Here, we show that two JMJ histone demethylases in Arabidopsis, EARLY FLOWERING 6 (ELF6) and RELATIVE OF EARLY FLOWERING 6 (REF6), play distinct roles in H3K27me3 and H3K27me1 homeostasis. We show that failure to reset these chromatin marks during sexual reproduction results in the inheritance of epigenetic imprints, which cause a loss of DNA methylation at heterochromatic loci and transposon activation. Thus, Jumonji-type histone demethylases in plants contribute towards maintaining distinct transcriptional states during development and help safeguard genome integrity following sexual reproduction.
Source: eLife
DOI: 10.7554/elife.58533
Authors: Javier Antunez-Sanchez, Matthew Naish, Juan Sebastian Ramirez-Prado, Sho Ohno, Ying Huang, Alexander Dawson, Korawit Opassathian, Deborah Manza-Mianza, Federico Ariel, Cecile Raynaud, Anjar Wibowo, Josquin Daron, Minako Ueda, David Latrasse, R Keith Slotkin, Detlef Weigel, Moussa Benhamed, Jose Gutierrez-Marcos
Institutions: University of Warwick, University of Cambridge, Centre National de la Recherche Scientifique, Université Paris-Saclay, Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement, Institut des Sciences des Plantes de Paris Saclay, Kyoto University, Universitas Airlangga, Max Planck Institute for Developmental Biology, Institut de Recherche pour le Développement, The Ohio State University, Institute of Transformative Bio-Molecules, Nagoya University, Donald Danforth Plant Science Center, University of Missouri, Université Paris Cité, Tohoku University
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $2,500
Awards: 14 ERA-CAPS.EVOREPRO.Evolution of Sexual Reproduction in Plants, Comprehensive imaging of intracellular dynamics and homemade compounds to elucidate the mechanism of asymmetric division in plants., G2121312962, G36460806, Integrated approaches to plant sexual reproduction studies to enhance food security, G5283005851, G5368808017, G6106246839, G6497730688, G6587299157, Molecular mechanisms of the determination of the apical-basal axis and pattern formation along the axis in plants., G6994769724, Control of early embryogenesis by extra-embryonic peptides, G7368843736, 18-BTT:Harnessing the power of cellular memory to enhance the breeding potential of crops, Regulation of the male germline in cereal crops by somatic companion cells, G842591340, G8924239800, G9000346736
OpenAlex ID: W3094258389