Work

EIF3H interacts with PDCD4 enhancing lung adenocarcinoma cell metastasis.

Year: 2020

Type: article

Abstract: as well as metastasis in nude mice by activating epithelial-mesenchymal transition (EMT) signaling. Conversely, EIF3H knockdown with small interfering RNAs reversed these changes in LUAD cells. Furthermore, we discovered that introduction of PDCD4 to EIF3H-overexpressing LUAD cells abrogated the function of EIF3H, reducing migration and invasion of LUAD cells by downregulating EMT signaling. Taken together, our findings identified a previously unknown negative regulation of PDCD4 on EIF3H and confirmed EIF3H as an oncogenic factor in LUAD by enhancing EMT signaling, which was abrogated by PDCD4.

Source: PubMed Central

Authors: Yingying Hu, Xiao Wei, Yumin Lv, Xin Xie, Liu Yang, Jingjing He, Xingyu Tao, Yuting Ma, Yun Su, Liyang Wu, Weiyi Fang, Zhen Liu

Institutions: State Key Laboratory of Respiratory Disease, Guangzhou Medical University, Southern Medical University

Language: English

Topic: Mechanisms of cancer metastasis

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W3009228336

FWCI: 0.929

Cites: 43

Cited by: 21

Related to: 10