Work

Direct genome editing of patient-derived xenografts using CRISPR-Cas9 enables rapid in vivo functional genomics

Year: 2020

Type: article

Source: Nature Cancer

DOI: 10.1038/s43018-020-0040-8

Authors: Christopher H. Hulton, Emily A. Costa, Nisargbhai S. Shah, Alvaro Quintanal-Villalonga, Glenn Heller, Elisa de Stanchina, Charles M. Rudin, John T. Poirier

Institutions: Memorial Sloan Kettering Cancer Center, Weill Cornell Medicine, NYU Langone Health, NYU Langone’s Laura and Isaac Perlmutter Cancer Center, New York University

Language: English

Topic: CRISPR and Genetic Engineering

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: U.S. Department of Health and Human Services, National Institutes of Health, National Eye Institute, National Cancer Institute

Awards: G1007166040, G1461039127, Identification and validation of synthetic lethality in KRAS mutant lung adenocarcinoma patient derived xenografts, G2684890037, G2840623023, G3117500281, Targets for Therapy for Carcinomas of the Lung, G4651258030, G4936166682, G7014621378, Coordinating center for the NCI small cell lung cancer research consortium, Cancer Center Support Grant

OpenAlex ID: W3009464686

FWCI: 1.936

Cites: 69

Cited by: 49

Related to: 10