Work

Intracellular Control of β-Catenin and Intestinal Cell Fate by SIRT2

Year: 2020

Type: article

Abstract: Tight coordination of cell proliferation and differentiation is critical for the health of the intestinal epithelium, which accomplishes rapid and continuous turnover while maintaining a complex morphology and a regulated balance of stem, absorptive, and secretory cell populations. Disruption of this equilibrium can contribute to disorders such as inflammatory bowel disease (IBD) or colon cancer. At the same time, the epithelium needs to be able to dynamically alter its self-renewal and differentiation programs to protect against infection, injury, or chronic inflammation.

Source: Cellular and Molecular Gastroenterology and Hepatology

DOI: 10.1016/j.jcmgh.2020.02.003

Author: Mark R. Frey

Institutions: University of Southern California, Children's Hospital of Los Angeles, Saban Research Institute

Language: English

Topic: Sirtuins and Resveratrol in Medicine

Subfield: Geriatrics and Gerontology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,000